{"id":173,"date":"2008-09-05T09:09:40","date_gmt":"2008-09-05T14:09:40","guid":{"rendered":"http:\/\/www.brainybehavior.com\/blog\/?p=173"},"modified":"2008-09-05T09:09:40","modified_gmt":"2008-09-05T14:09:40","slug":"learning-and-recall-hippocampal-firing","status":"publish","type":"post","link":"https:\/\/www.brainybehavior.com\/blog\/2008\/09\/learning-and-recall-hippocampal-firing\/","title":{"rendered":"Learning and Recall &#8211; Hippocampal Firing"},"content":{"rendered":"<div class=\"bawot69fcbb4f420ff\" ><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- Mobile in post -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:inline-block;width:320px;height:100px\"\r\n     data-ad-client=\"ca-pub-0039142346952764\"\r\n     data-ad-slot=\"1620587573\"><\/ins>\r\n<script>\r\n(adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><\/div><style type=\"text\/css\">\r\n.bawot69fcbb4f420ff {\r\nmargin: 5px; padding: 0px;\r\n}\r\n@media screen and (min-width: 1201px) {\r\n.bawot69fcbb4f420ff {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 993px) and (max-width: 1200px) {\r\n.bawot69fcbb4f420ff {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 769px) and (max-width: 992px) {\r\n.bawot69fcbb4f420ff {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 768px) and (max-width: 768px) {\r\n.bawot69fcbb4f420ff {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (max-width: 767px) {\r\n.bawot69fcbb4f420ff {\r\ndisplay: block;\r\n}\r\n}\r\n<\/style>\r\n<p>Today in Science a team of scientists (Hagar Gelbard-Sagiv, Roy Mukamel, Michal Harel, Rafael Malach, and \u00a0Itzhak Fried)\u00a0at the\u00a0Weizmann Institute of Science in Israel,\u00a0UCLA, and Tel Aviv University published their research where they directly recorded via implanted electrodes the firing of hippocampus neurons during learning and free recall. This represents the first time in humans this has been done. Here&#8217;s the abstract from Science:<\/p>\n<blockquote><p>The emergence of memory, a trace of things past, into human consciousness is one of the greatest mysteries of the human mind. Whereas the neuronal basis of recognition memory can be probed experimentally in human and nonhuman primates, the study of free recall requires that the mind declare the occurrence of a recalled memory (an event intrinsic to the organism and invisible to an observer). Here, we report the activity of single neurons in the human hippocampus and surrounding areas when subjects first view television episodes consisting of audiovisual sequences and again later when they freely recall these episodes. A subset of these neurons exhibited selective firing, which often persisted throughout and following specific episodes for as long as 12 seconds. Verbal reports of memories of these specific episodes at the time of free recall were preceded by selective reactivation of the same hippocampal and entorhinal cortex neurons. We suggest that this reactivation is an internally generated neuronal correlate of the subjective experience of spontaneous emergence of human recollection. (Published Online September 4, 2008;\u00a0Science DOI: 10.1126\/science.1164685)<\/p><div class=\"yjabx69fcbb4f42150\" ><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Mobile in post -->\n<ins class=\"adsbygoogle\"\n     style=\"display:inline-block;width:320px;height:100px\"\n     data-ad-client=\"ca-pub-0039142346952764\"\n     data-ad-slot=\"1620587573\"><\/ins>\n<script>\n(adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><\/div><style type=\"text\/css\">\r\n.yjabx69fcbb4f42150 {\r\nmargin: 5px; padding: 0px;\r\n}\r\n@media screen and (min-width: 1201px) {\r\n.yjabx69fcbb4f42150 {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 993px) and (max-width: 1200px) {\r\n.yjabx69fcbb4f42150 {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 769px) and (max-width: 992px) {\r\n.yjabx69fcbb4f42150 {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 768px) and (max-width: 768px) {\r\n.yjabx69fcbb4f42150 {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (max-width: 767px) {\r\n.yjabx69fcbb4f42150 {\r\ndisplay: block;\r\n}\r\n}\r\n<\/style>\r\n<\/blockquote>\n<p>The New York Times also has an <a href=\"http:\/\/www.nytimes.com\/2008\/09\/05\/science\/05brain.html?_r=3&amp;partner=rssnyt&amp;emc=rss&amp;oref=slogin&amp;oref=slogin&amp;oref=slogin\">article<\/a> about the research.<\/p>\n<div class=\"eotch69fcbb4f4217a\" ><script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- Mobile in post -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:inline-block;width:320px;height:100px\"\r\n     data-ad-client=\"ca-pub-0039142346952764\"\r\n     data-ad-slot=\"1620587573\"><\/ins>\r\n<script>\r\n(adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><\/div><style type=\"text\/css\">\r\n.eotch69fcbb4f4217a {\r\nmargin: 5px; padding: 0px;\r\n}\r\n@media screen and (min-width: 1201px) {\r\n.eotch69fcbb4f4217a {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 993px) and (max-width: 1200px) {\r\n.eotch69fcbb4f4217a {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 769px) and (max-width: 992px) {\r\n.eotch69fcbb4f4217a {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (min-width: 768px) and (max-width: 768px) {\r\n.eotch69fcbb4f4217a {\r\ndisplay: block;\r\n}\r\n}\r\n@media screen and (max-width: 767px) {\r\n.eotch69fcbb4f4217a {\r\ndisplay: block;\r\n}\r\n}\r\n<\/style>\r\n","protected":false},"excerpt":{"rendered":"<p>Today in Science a team of scientists (Hagar Gelbard-Sagiv, Roy Mukamel, Michal Harel, Rafael Malach, and \u00a0Itzhak Fried)\u00a0at the\u00a0Weizmann Institute of Science in Israel,\u00a0UCLA, and Tel Aviv University published their research where they directly recorded via implanted electrodes the firing of hippocampus neurons during learning and free recall. This represents the first time in humans &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.brainybehavior.com\/blog\/2008\/09\/learning-and-recall-hippocampal-firing\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Learning and Recall &#8211; Hippocampal Firing&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,24,30,25,18,38],"tags":[258,253,262,100],"class_list":["post-173","post","type-post","status-publish","format-standard","hentry","category-brain","category-cognition","category-hippocampus","category-learning","category-memory","category-neuroscience","tag-hippocampus","tag-memory","tag-neuroscience","tag-recall"],"_links":{"self":[{"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/posts\/173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/comments?post=173"}],"version-history":[{"count":1,"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/posts\/173\/revisions"}],"predecessor-version":[{"id":174,"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/posts\/173\/revisions\/174"}],"wp:attachment":[{"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/media?parent=173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/categories?post=173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.brainybehavior.com\/blog\/wp-json\/wp\/v2\/tags?post=173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}