First Successful Brain Transplant

Recently, French scientists at the University of Southern North Dakota – Baltimore performed the first successful human brain transplant. Said the chief neurosurgeon, Dr. Cranial Head, MD, “This is a breakthrough of unprecedented magnitude. I’m ecstatic all our research and hard work finally paid off. We couldn’t be more pleased with how things turned out.”

The patient, who only agreed to be called Jose Ivanovich O’Malley, III for anonymity reasons, suffered a massive anterior communicating arterial stroke that left him severely incapacitated. He was a veterinarian at a local clinic before his stroke. His family heard about the research Dr. Head’s team was doing with rats and contacted him about the possibility of being his first human subject. Dr. Head agreed immediately, “I saw this as the perfect opportunity to advance our research out of animals and into humans. We’ve had great success – recently – with brain transplants in rats so it was only logical to start human trials.”

“This new brain transplant surgery is quite remarkable,” said Dr. Head. “My colleague, Dr. Sarah Wu, and I first came up with the idea 40 years ago while we were competing in a triathlon. It came out of the blue, really, neither of us are quite sure why we thought of it but here we are.”

What’s remarkable about the surgery is that it is done all under local anesthetic and the patient is kept talking throughout the procedure, except for the time when the brains are switched (during this time the patient is placed on life support). In this case, the transplanted brain came from a local high school physics teacher Stephen Cabeza who suffered an unexpected heart attack. He was not only young but also in good health. The Cabeza family wishes remain anonymous. The transplanted brain is removed from the original body and cooled to halt neuronal death. The end of the severed spinal column is treated with a new nanoglue that automatically splices individual axons to the new spinal cord when the transplant brain is placed on top.

“It’s incredible,” said Dr. Head, “surprisingly we don’t have much work to do because with this new nanoglue the process of reconnecting nerve fibers is automatic. It only takes 4 minutes. We just inspect the brain and spinal cord to make sure everything is lined up correctly. The nanoglue is also applied to areas like the optic nerves, that need to be spliced into the new brain.”

After the surgery, Jose made a speedy recovery. Within 24 hours he was moving his limbs and within a week he was walking and talking. His wife said, “It’s a miracle. We thought Jose was gone forever but Dr. Head saved him. He doesn’t know who any of us are, of course, and calls himself Stephen but we are all willing to work with the new Jose and learn to love him and hope he will learn to love us.” The medical team, however, remains baffled why Jose insists his name is Stephen. When asked if he planned on returning to work at his veterinary clinic, Jose stated that he couldn’t wait to return to teaching physics: “I’ve always had a love of physics. There’s something about gravity research that really attracts me.” Jose doesn’t remember any of his past self or his work as a veterinarian.

Disclaimer: this post was written in 2008 as an April Fool’s Day joke years before the idea of a head/body transplant was popularized by news media. It was written years before the “Fake News” trendy label. This post is completely made up and was written to be humorous. Surgeons cannot at the present time perform brain transplants, regardless of what is published online. The surgeon who claims he can perform a head transplant will not be successful. The idea of a brain/head/body replacement is interesting both as a potential medical advancement and as a point of ethical discussion. Is it theoretically possible? Yes. Will it happen anytime soon? No. Should it happen? That’s a discussion for another time.

Neuroscience and Marketing

There is a growing trend for marketing companies to turn to neuroscience in order to create better advertisements. Nielsen Entertainment Television Group now collaborates with NeuroFocus, a company that specializes in applying neurotechnology and neuroscience to marketing. NeuroFocus has some fairly well-known neuroscientists serving as advisors so their work should be pretty good. I hadn’t heard of the company before today but as I browsed their website I was intrigued. I recently completed a clinical rotation working at an anxiety disorders clinic. At the clinic all of the patients I saw were part of a research study investigating physiological arousal and emotion, specifically fear responses. Anyway, the patients were hooked up to sensors that measured skin conductance, eye blink, and other similar ways to measure physiological arousal. Some also received an EEG while viewing various photos.

My point is that the research that the company NeuroFocus is doing seems very valid knowing what we know about the physiological arousal associated with basic emotions. I think research like this is great because it has the potential for companies to make better, albeit more manipulative, commercials. All you need to do is look at physiological arousal and correlate the data from commercials with data from things like the International Affective Picture System. Of course, you can’t use the IAPS in for-profit work but a company could develop something similar. Even though I don’t do emotion research I think working at a place like NeuroFocus could be fascinating.

You can read more about using neuroscience in marketing in a short but good New York Times article.

Leukoaraiosis and Lacunes – A Very Brief Overview

As people age, it is common for their brain white matter to change. These changes often appear as bright white spots on T2-weighted MR scans. These areas or spots of hyperintensity (i.e., white matter hyperintensities {WMH}) are also called leukoaraiosis (LA). Researchers are still investigating the exact nature and pathology of these abnormalities but our understanding of them is increasing. They most often seem to start around the lateral ventricles and spread from there, although it is possible to have punctate WMH throughout the brain white matter (i.e., WMH that are not connected to other regions). WMH on brain MRIs represent rarefaction of the white matter, including swelling, demyelination, and damage, although the exact nature and combination of the white matter changes is not known. These WMH can interfere with normal cognitive functioning, including processing speed, attention, inhibition, as well as global executive functioning (although these claims are still being investigated).

Other damage to white matter includes lacunes, which are little holes in the brain, much like the holes in Swiss cheese. They are caused by mini infarcts, or strokes, or other processes. Most of the time they are due to “silent strokes”, or strokes that are small enough that the person does not have any noticeable stroke symptoms. These lacunes can have similar impact on cognition as WMH. Both WMH and lacunes are related to vascular risk factors, such as hyper- or hypo-tension, diabetes, etc.

New Blog Design

I updated my site with a new WordPress theme. I think it is a little cleaner than the previous theme. I’m still trying to decide what I want to do with the site redesign so I thought I’d do a quick little refresher for the time being, since it might take me a few more months to have the time to do a larger site redesign.

Building a Better Brain

Let’s look forward a number of years. Bioengineering is at the point where replacing people’s organs with lab-grown ones is standard procedure. Gone are the days of transplant patients taking anti-rejection medications for the rest of their lives. Transplanted organs are all manufactured using stem cells from their own body, from bone marrow or from skin or any number of different sources. New organs are rapidly grown using modified growth hormones to speed up their development. A complete new organ is grown within a few weeks, a surgery performed, and the transplant patient home within days. Because of the relative low cost of such procedures, all have access to transplants. Replacing hearts, livers, lungs, kidneys, and other organs increased the life expectancy dramatically with most people living well over 100 years. Scientists are on the verge of transplanting the first manufactured brain. Knowledge of neural networks and cognition is at the point where a person’s entire knowledge system and all memories can be downloaded and stored as a backup. Scientists are working on manufacturing an entire replica human body as a “clone” in case a person is seriously injured. While individual organs come fairly cheap, a whole body is prohibitively expensive. A large portion of the cost is the brain. Even though scientists have created working brains, their success rate is still only about 5% (but always getting better). They go through a lot of brains.

Some people use this new biotechnology for creating backups of their bodies. Other people have started using it to enhance the performance of their existing body. In laboratory situations scientists are able to create organs that are effectually perfect. They are created in well-controlled situations and don’t have to go through the gauntlet of normal development, with exposure to teratogens, fluctuations in nutrition, and all the other things that can affect development. Popular organs to replace are hearts and lungs. People are able to run faster than ever before due to more efficient hearts and lungs. Other people get new legs or arms with well-sculpted muscles. Still other receive nanotech implants to enhance normal biological performance. None of this is being done in the United States or in the United Kingdom but there are plenty of countries that don’t outlaw the procedures

With the common body enhancing going on many people want to enhance their brains. They want a new brain created with certain gyri a little bit bigger and cortex a little bit thicker. Some researchers are working on improving the speed and efficiency of neurotransmitting. Most of the improvements in brain design come from turning on and off certain genes at different time points in development and providing the lab-grown brains optimal nutrients and stimulation. These enhancements can create brains that can learn 1000 times more in 1000 times less time.

I’ve taken a bit of liberty in my hypothetical treatment of bioengineering and biotechnology in the unspecified future. There is little, scientifically-speaking, that stands in the way of us as humans eventually reaching this point. The question is, should we? Should we seek to create immortal and essentially all-knowing humans through science. Supposing humans can build better brains and bodies, should they control and manipulate natural biological processes to the extent that they can create “superbeings”? I’m not going to answer any of the questions; I just want to raise them. With our great advances in bioengineering, technology, and neuroscience, where do we draw the line, assuming we do draw a line? Do we eradicate all developmental, genetic, and environmental diseases and disorders. Do we cure epilepsy, cancer, Autism, Alzheimer’s Disease, and ever other disorder? Do we enhance some functioning, such as hearts or muscles but not the brain?

With all advances in science, we have to always be mindful of the underlying morality and ethics of the advances. we need to make sure that our advances do not out-pace our morals.

The Guillotine and Neuroscience

The air was chilly in 19th Century Paris as a criminal was led to his fate. A GuillotineThe man had committed a crime and was sentenced to pay. A crowd gathered to watch his punishment. There standing before him was the fateful Madame, the progeny of a French engineer. This Woman with the acerbic jaw was to seal the criminal’s fate. He faced the crowd wide-eyed and fearful, pleading for his life. His pleas seemed to fall on deaf ears as the frenzied crowd prepared for the spectacle. A German man stood waiting to play his part. Theodor Bischoff was not there to enjoy the public execution, he was there in the name of science. As the executioner led the criminal to the apparatus named after Joseph Guillotin (who by the way did not invent the guillotine), Bischoff approached. The blade fell and the criminal’s head dropped to the ground. Bischoff quickly rushed over to the head to perform his experiment.

Bischoff wanted to know whether or not consciousness was centered in the head – in the brain – and if any awareness resided after the beheading. He quickly thrust his fingers at the poor criminal’s eyes to see if there was any eye-blink. There was none. He placed smelling salts under the nose, with no reaction. Finally he spoke the word, “Pardon!” into an ear. Again, no response. He was satisfied with the results and concluded that consciousness did in fact reside in the brain and that it ended when the head was severed. His early neuroscience experiment was complete.

While this approach seems unorthodox at best today, early researchers had to resort sometimes to interesting techniques in order to investigate the influence of the brain on behavior, emotions, and consciousness. Their research methods were often seriously flawed but the work they did was important. Each new discovery led to our current understanding of the brain. So while we have much better methods to research the brain than antagonizing disembodied heads, our current research as neuropsychologists and neuroscientists is founded on the research of such creative men as Bischoff.

Note: I dramatized the story and as such, it is a bit of historical fiction. I don’t know if Bischoff was in Paris, he might have been in Germany when he did the experiment. However, Bischoff did perform this experiment.

Biological Determinism

Free WillAs someone with a strong neurobiological foundation, I believe that the brain is the center of all behavior. What is the evidence for that belief? Remove someone’s brain and see if they have any behavior (note: I’m not endorsing this behavior, I’m merely postulating a hypothetical situation). Without the brain, there is no behavior. So, the brain is necessary for behavior but is it sufficient?

In psychology we often talk about necessary and sufficient conditions for behavior. That is, you may need a certain factor in order for a behavior to happen but without other factors, the behavior will not occur. For example, you need water to live – it is necessary – but you also need food, so thus not sufficient. So, the brain is necessary for behavior but can all behavior be explained solely by the brain? Another way of phrasing this question is, “Does biology determine all behavior?” The term for this belief is biological determinism.

To answer the question we first have to investigate and uncover other potential influences on (causes of) behavior. If behavior is biologically determined, do people have free will? That is, do people really have the ability to consciously make and choose different behavior? Or are all behaviors simply determined at the neuronal (or genetic) level and free will is only an illusion? This post is an expansion on one of my previous posts concerning alternative assumptions to naturalism in neuroscience.

If you really believe that the brain (and by reductionism, genes) are solely responsible for behavior, then you cannot believe that people have free will. You also cannot believe that the environment is directly responsible for behavior – it can influence it – but at the core, your genes and your neurons create behaviors. Alternatively, you can believe that humans have free will, that we can make choices because of or in spite of our biology. Agency can influence biology and biology can influence agency – they are not mutually exclusive categories. While the brain is a necessary condition for behavior, it is not sufficient; agency is a factor in human behavior.

Attractiveness and Social Perception

An example of how people judge others based on attractiveness. There is a lot of social psychology research showing that attractive people are treated better, trusted more, liked more, and viewed more favorably even if they are complete strangers.
clipped from www.uni-regensburg.de

Attractive female faces:?

Unattractive female faces:?

All faces do not exist in reality. They were created by
using morphing software. Nevertheless, most of the test subjects have no
problem to attribute certain personality characteristics to them.

Classic Asch Conformity Experiment

Great little video of a historic social psychology experiment about the power of social influence and our desire to conform.
clipped from www.youtube.com

New CT Scanner from Philips

Philips recently developed a new 64 channel CT scanner that can provide high-resolution 3-D images of the body. The images it can produce are simply fabulous. Philips states that it can have sub-milimeter isotropic resolution and scan the complete human body in less than one minute with 80% less radiation exposure than traditional CT scanners. Numerous articles and pictures are starting to show up on the web. It appears that the main uses of it, at least initially, are focused on the cardiovascular system. I wonder how beneficial or useful it would be for neuroimaging? I’m not an imaging specialist but the speed and resolution of this system could lead to great improvements in neuroimaging. Even with a limited field of view, it seems like it could be beneficial to look at specific regions of the brain. There is no indication if volumetric and quantitative analyses could be performed on the images. Then again, the technology is quite new. Only one hospital in the world is actually using one of these machines.

The reported price of the machine is $2 million, which is quite reasonable. MRI machines can run upwards of $10 million. This is a technology well worth watching as it develops. We are about to enter a golden age of anatomical imaging.

Here are a few links to stories and images:

Image Gallery

Gizmodo article

Technical Specs

BBC article

CT image

CT image of face

Images by Philips.

Toshiba also recently unveiled a similar machine: Link here.